B.S., Analytical Chemistry, Lanzhou University, Lanzhou
M.S., Radiochemistry, Lanzhou University, Lanzhou
Ph.D., Physical Chemistry, Peking University, Beijing
Biomaterials, Bio-Nanotechnology, Tissue Engineering and Regenerative Medicine
Chen’s lab focuses on the development of novel biomaterials for tissue repair and drug delivery using biomimetics principles and nanotechnologies. We are studying tooth regeneration, scaffolds for tissue engineering and dental materials.
Tooth regeneration: Tooth decay is a widespread infectious disease experienced by most of the population due to dental disease, natural abrasion and aging. The aim of this research is to take advantage of the latest developments of nanotechnology, together with the basic knowledge of the biological processes involved in tooth development, to regenerate the biomimetic dental structure for dental care.
Scaffolds for Tissue Engineering: The research scheme is to apply hydrogel and electrospun nanofibers to fabricate nanoscaffolds to mimic the structure of natural extracellular matrix (ECM) which is able to promote the migration of cells and facilitate the growth of blood vessels into the scaffolds.
Dental Materials: We are interested in developing nanocomposite, resin, cement, coating and ceramics for dental clinic.
Professional Honors and Awards
University of Michigan at Ann Arbor, NIH Research Fellow, 2001-2002.
University of Leeds, Leeds Teaching Hospital NHS Trust Research Fellow, 1999-2001.
Committee Member: Awards Review Committee (International Association for Dental Research)
Member: Chemical Society of China
Selected Recent Publications
1. Clarkson BH and Chen H: Methods for Production and Use of Synthetic Hydroxyapatite and Fluorapatite Nanorods, and Superstructures Assembled from the Same. United States Patent No.: US7,879,388 B2. Date of Patent: Feb.1. 2011.
2. Li C, Wang L, Yang Z, Kim G, Chen H, Ge H. A Viscoelastic Chitosan-modified three-dimensional Porous Poly (L-lactide-co-ε-caprolactone) Scaffold for Cartilage Tissue Engineering. Journal of Biomaterials Science: Polymer Edition (2011). DOI: 10.1163/092050610X551970
3. Yun S, Ge Y, Yin Y, Feng H, Chen H:in vitro Study of a Novel Method to Repair Human Enamel, in Biological Materials and Structures in Physiologically Extreme Conditions and Disease, edited by M.J. Buehler, D. Kaplan, C.T. Lim, J. Spatz (Mater. Res. Soc. Symp. Proc. Volume 1274, Warrendale, PA, 2010), 1274-QQ08-10
4. Yin Y, Yun S, Fang J, Chen H: Chemical Regeneration of Human Tooth Enamel under Near-Physiological Conditions, Chemical Communications, 2009, 39, 5892-5894
5. Wang X, Xia C, Zhang Z, Deng X, Wei S, Zheng G, Chen H: Direct Growth of Human Enamel-like Calcium Phosphate Microstructures on Human Tooth, Journal of Nanoscience and Nanotechnology, 9, Sp. Iss. 1361-1364, 2009
6. Chen H, Wood D, Chang SR, Czajka-Jakubowska A, Clarkson BH. Synthesis of fluorapatite (FA) nanorods and surfaces. Pol. J. Environ. Stud. Vol 16 No. 2C Pt. 2 s. 279-282, 2007
7. Chen H, Tang Z, Liu J, Sun K, Chang SR, Peters MC, Mansfield JF, Czajka-Jakubowska A, Clarkson BH: Acellular synthesis of a Human Enamel-like Microstructure, Advanced Materials, 18: 1846-1851, 2006
8. Chen H, Czajka-Jakubowska A, Spencer NJ, Mansfield JF, Robinson C, Clarkson BH: Effects of Systemic Fluoride and in vitro Fluoride Treatment on Enamel Crystals, Journal of Dental Research, 85：1042-1045，2006
9. Chen H, Sun K, Tang Z, Law RV, Mansfield JF, Czajka-Jakubowska A, Clarkson BH: Synthesis of Fluorapatite Nanorods and Nanowires by Direct Precipitation from Solution, Crystal Growth & Design, 6: 1504-1508, 2006.
10. Chang S, Chen H, Liu J, Wood D, Bentley P, Clarkson B: Synthesis of a bioactive, hydroxyapaptite nucleating molecule, Calcified Tissue International, 78: 55-61, 2006.
11. Chen H, Robinson C, Shore RC, Brookes SJ, Zhang J, Smith DA, Clarkson BH, Kirkham J: Nanoscale analysis of bone mineral crystals, NSTI-Nanotech 2006, ISBN 0-9767985-7-3 Vol. 2: 95-98, 2006
12. Czajka-Jakubowska A, Chen H, Clarkson BH. A new generation of microscope for imaging biological samples. Dental Forum 34(1):9-14, 2006.
13. Chen H, Clarkson BH, Sun K, Mansfield JF: Self-assembly of synthetic hydroxyapatite nanorods into an enamel prism-like structure, Journal of Colloid and Interface Science, 288: 97-103, 2005.
14. Czajka-Jakubowska A, Chen H, Clarkson BH, Siepak J, Stopa J: The influence of fluoride administered in drinking water on enamel crystal topography, Pol. J. Enviorn. Stud. Vol. 14 suppl. 5s:49-54, 2005.
15. Chen H, Chen Y, Orr BG, Banaszak-Holl MM, Majoros I, Clarkson BH: Nanoscale probing of enamel nanorod surface using polyamidoamine dendrimer, Langmuir 20(10): 4168-4171, 2004.
16. Harrell JM, Murphy PJM, Morishima Y, Chen H, Mansfield JF, Galigniana MD, Pratt WB: Evidence for glucocorticoid receptor transport on microtubules by dynein, Journal of Biological Chemistry, 279(52): 54647-54654, 2004
17. Chen H, Banaszak-Holl MM, Orr BG, Majoros I, Clarkson BH: Interaction of Dendrimers (Artificial Proteins) with Biological Hydroxyapatite Crystals, Journal of Dental Research 82(6): 443-448, 2003.
18. Murphy PJM, Morishima Y, Chen H, Galigniana MD, Mansfield JF, Simons SS and Pratt WB: Visualization and Mechanism of Assembly of a Glucocorticoid Receptor-hsp70 Complex that is Primed for Subsequent hsp90-Dependent Opening of the Steroid Binding Cleft, Journal of Biological Chemistry 278(37):34764-34773, 2003.
19. Wallwork ML, Kirkham J, Chen H, Chang SR, Robinson C, Clarkson BH: Imaging Dentin Proteins on Enamel Crystal Using Atomic Force Microscopy, Calcified Tissue International 71:249-255, 2002.
20. Kirkham J, Brooks SJ, Shore RC, Wood SR, Smith DA, Zhang J, Chen H, Robinson C: Physico-chemical properties of crystal surfaces in matrix-mineral interactions during mammalian biomineralisation. Current Opinion in Colloid & Interface Science 7(1-2):124-132, 2002.