Seeking suitable biomaterials for soft tissues
| Biomaterial approaches to tissue repair & regeneration have been utilized to manage injury, damage and diseases of soft tissues, such as muscle and blood vessel. Seeking a suitable biomaterial for such use is very complex and highly significant. It is expected that the biomaterial is compatible and mimetic to the native tissue, liking a harmony between artificialization and nature. Our lab aims to utilize structure-properties-function relationship to seek suitable biomaterials for soft tissue repair, through utilities of both synthetic and natural material concepts. Due to softness and elasticity of the soft tissues, we focus on a synthetic elastic biodegradable polymer, polyurethane, with controlled degradation, tunable mechanical properties, blood compatibility and conductivity. In terms of tissue extracellular matrix complex, decellularized materials were investigated in our lab. Furthermore, we also developed robust elastic hydrogels for bioprinting, and bioadhesives for tissue gluing. The development of these materials may provide some hints for inspiring new generation of biomaterials.