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Kuangda Lu
Ph.D., Assistant Professor
Department of Biomedical Engineering
Peking University
  • Office Add: PKUCare Industrial Park Building 12 Room 203
  • OfficeTel: +86-18211026017
  • LabAdd: PKUCare Industrial Park Building 13 Room 215
  • Email: lukuangda@hsc.pku.edu.cn

Research Area

Nanomedicine, Biomaterials, Cancer photo therapies, radiation therapy and immunotherapy

Education

Ph.D. in Chemistry;   The University of Chicago                   2016

B.S.;     Peking University                                                    2011

Major Professional Experiences

2018.09-Present Assistant Professor, Department of Biomedical Engineering, Peking University

2016.09-2018.09 Postdoctoral Scholar, Department of Radiation Oncology and Department of Chemistry, The University of Chicago

Selected Awards

American Chemical Society Young Investigator Award (Division of Inorganic Chemistry).   2017

American Chemical Society Yao Yuan Award of Medicinal Chemistry, Second Place.  2017

Major Publications

  1. Lu, K.; He, C.; Guo, N.; Chan, C.; Ni, K.; Lan, G.; Tang, H.; Pelizzari, C.; Fu, Y.-X.; Weichselbaum, R. R.; Lin, W. Low-dose X-ray Radiotherapy-Radiodynamic Therapy via Nanoscale Metal-Organic Frameworks Enhances Checkpoint Blockade Immunotherapy. Nat. Biomed. Eng. 2018, 2, 600-610
  2. Lu, K.; Aung, T.; Guo, N.; Weichselbaum, R. R.; Lin, W. Nanoscale Metal-Organic Frameworks for Therapeutic, Imaging, and Sensing Applications. Adv. Mater. 2018, 30 (37), 1707634
  3. Lu, K.; He, C.; Guo, N.; Chan, C.; Ni, K.; Weichselbaum, R. R.; Lin, W. Chlorin-Based Nanoscale Metal−Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy. J. Am. Chem. Soc. 2016, 138 (38), 12502-12510
  4. Lu, K.; He, C.; Lin, W. A Chlorin-Based Nanoscale Metal−Organic Framework for Photodynamic Therapy of Colon Cancers. J. Am. Chem. Soc. 2015, 137 (24), 7600-7603
  5. Lu, K.; He, C.; Lin, W. Nanoscale Metal–Organic Framework for Highly Effective Photodynamic Therapy of Resistant Head and Neck Cancer. J. Am. Chem. Soc. 2014, 136 (48), 16712-16715
  6. He, C.#; Lu, K.#; Lin, W. Nanoscale Metal–Organic Frameworks for Real-Time Intracellular pH Sensing in Live Cells. J. Am. Chem. Soc. 2014, 136 (35), 12253-12256 (Co-First Author)
  7. He, C.; Lu, K.; Liu, D.; Lin, W. Nanoscale Metal–Organic Frameworks for the Co-Delivery of Cisplatin and Pooled siRNAs to Enhance Therapeutic Efficacy in Drug-Resistant Ovarian Cancer Cells. J. Am. Chem. Soc. 2014, 136 (14), 5181-5184
  8. Liu, D.; Lu, K.; Poon, C.; Lin, W. Metal–Organic Frameworks as Sensory Materials and Imaging Agents. Inorg. Chem. 2013, 53 (4), 1916-1924
  9. Liu, D.; Poon, C.; Lu, K.; He, C.; Lin, W. Self-assembled Nanoscale Coordination Polymers with Trigger Release Properties for Effective Anticancer Therapy. Nat. Comm. 2014, 5, 4182
  10. Ni, K.; Lan, G.; Chan, C.; Quigley, B.; Lu, K.; Aung, T.; Guo, N.; La Riviere, P.; Weichselbaum, R. R.; Lin, W. Nanoscale Metal-Organic Frameworks Enhance Radiotherapy to Potentiate Checkpoint Blockade Immunotherapy. Nat. Comm. 2018, 9, 2351
  11. Lan, G.; Ni, K.; Xu, R.; Lu, K.; Lin, Z.; Chan, C.; Lin, W. Nanoscale Metal–Organic Layers for Deeply Penetrating X-ray-Induced Photodynamic Therapy. Angew. Chem. Int. Ed. 2017, 56, 1-6
  12. Xu, R.; Wang, Y.; Duan, X.; Lu, K.; Micheroni, D.; Hu, A.; Lin, W. Nanoscale Metal–Organic Frameworks for Ratiometric Oxygen Sensing in Live Cells. J. Am. Chem. Soc. 2016, 138(7), 2158-2161
  13. Dai, R.; Peng, F.; Ji, P.; Lu, K.; Wang, C.; Sun, J.; Lin, W. Electron Crystallography Reveals Atomic Structures of Metal–Organic Nanoplates with M12(μ3-O)8(μ3-OH)8(μ2-OH)6(M=Zr, Hf) Secondary Building Units. Inorg. Chem. 2017, 56 (14), 8128-8134
  14. Poon, C.; He, C.; Liu, D.; Lu, K.; Lin, W. Self-assembled Nanoscale Coordination Polymers Carrying Oxaliplatin and Gemcitabine for Synergistic Combination Therapy of Pancreatic Cancer. J. Control. Release. 2015, 201, 90-99
  15. Wang, C.; Volotskova, O.; Lu, K.; Ahmad, M.; Sun, C.; Xing, L.; Lin, W. Synergistic Assembly of Heavy Metal Clusters and Luminescent Organic Bridging Ligands in Metal–Organic Frameworks for Highly Efficient X-ray Scintillation. J. Am. Chem. Soc. 2014, 136 (17), 6171-6174
  16. Abney, C.W.; Gilhula, J. C.; Lu, K.; Lin, W. Metal-Organic Framework Templated Inorganic Sorbents for Rapid and Efficient Extraction of Heavy Metals. Adv. Mater. 2014, 26, 7993–7997

Patents

         Wenbin Lin, Chunbai He, Kuangda Lu, Kaiyuan Ni, Guangxu Lan. Nanoparticles for Photodynamic Therapy, X-ray Induced Photodynamic Therapy, Radiotherapy, Chemotherapy, Immunotherapy, And Any Combination Thereof. US Patent Application 2018/0153796.