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Yunlong Huo
Ph.D., Associate Professor
Associate Professor,
Department of Mechanics and Engineering Science,
College of Engineering, Peking University
  • Office Add: Mechanics Building 507, College of Engineering, Peking University, Beijing 100871
  • Office Tel: +86-10-62755417
  • Email: yhuo@pku.edu.cn

Education

Ph.D. Mechanical Engineering, Washington State University, Pullman, WA, US, 2005

M.S. Mechanical Engineering, National University of Singapore, Singapore, 2001

B.S. Hydraulic Engineering, Tsinghua University, Beijing, China, 1999


Professional Experience

12/2012-present Associate Professor, College of Engineering, Peking University, China

07/2006-12/2012 Assistant Research Professor, Departments of BME and Physiology, IUPUI

08/2005-06/2006 Postdoc Researcher, BME Department, University of California at Irvine (UCI)

Research Interests

My research interests are in the areas of: a) cardiovascular biomechanics (e.g., coronary circulation and tissue mechanics) related to stenosis, hypertension, and heart failure, b) mechanobiology (e.g., oxidative stress and redox signaling in endothelium and integrin-mediated mechanotransduction in smooth muscle cells) for arterial stiffness and aging, and c) innovative diagnosis and bioinstrumentation.  Most of the present work makes use of physical principles, with the help of bio-imaging techniques, physiological measurements in large animal models or patients, and theoretical analysis, to explain and predict coronary heart diseases in quantitative and statistical terms.


Research Support

1. Natural Science Foundation of China: “Structure-functional remodeling of coronary vasculature in heart failure caused by coronary heart disease”, RMB 860,000, PI, 2014-2017.

2. Singapore – China 10th Joint Research Programme Grant: “Imaging-based diagnosis of diffuse coronary artery disease and quantification of cardiac remodeling in obesity”, RMB 750,000 + Singapore Dollar 300,000, PI, 2014-2017.

3. 1000Plan of Young Talent in China, RMB 3,000,000, PI, 2013-2016

4. American Heart Association – Scientist Development Grant, “Analysis of Coronary Flow in Acute Stenosis”, US Dollar 308,000, PI, 2008-2011

5. National Institute of Health –R01 Grant, “CT-based diagnosis of diffuse coronary artery disease”, US Dollar 1,800,000, Co-Investigator (PI: Ghassan S. Kassab in IUPUI), 2009-2013


Journal Papers (2004-present)

Website at Google Scholar: http://scholar.google.com/citations?user=ogefOREAAAAJ&hl=en

Journal Papers in Cardiac and Cardiovascular System

  1. X. Chen, L. Guo, J. Kang, Y. Huo, S. Wang, W. Tan, Calcium waves initiating from the anomalous subdiffusive calcium sparks, Journal of the Royal Society Interface (Impact factor 4.907)?In press?http://www.ncbi.nlm.nih.gov/pubmed/24335558
  2. Y. Huo, S. Choy, T. Wischgoll, T. Luo, S. D. Teague, D. L. Bhatt, and G. S. Kassab, Computed tomography-based diagnosis of diffuse compensatory enlargement of coronary arteries using scaling power laws, Journal of the Royal Society Interface (Impact factor 4.907), In press, http://www.ncbi.nlm.nih.gov/pubmed/23365197
  3. B. Su, Y. Huo, G. S. Kassab, F. Kabinejadiand, S. Kimd, H. L. Leod, L. Zhong, Numerical investigation of blood flow in three-dimensional porcine left anterior descending artery with various stenosis, Computers in Biology and Medicine, (Impact factor 1.359), 47C:130-138, 2014
  4. T. Luo, T. Wischgoll, B. K. Koo, Y. Huo, G. S. Kassab, IVUS Validation of Patient Coronary Artery Lumen Area obtained from CT Images, PLoS ONE (Impact factor 3.730), 9: e86949, 2014
  5. Y. Huo, T. Luo, J. M. Guccione, S. D. Teague, W. Tan, J. A. Navia and G. S. Kassab, Mild anastomotic stenosis in patient-specific CABG model may enhance graft patency: a new hypothesis, PLoS ONE (Impact factor 3.730), 8:e73769, 2013
  6. Y. Huo, T. Wischgoll, S. Choy, S. Sola, J. L. Navia, S. D. Teague, D. L. Bhatt, and G. S. Kassab, CT-based diagnosis of diffuse coronary artery disease on the basis of scaling power laws, Radiology (Impact factor 6.339), 268:694-701, 2013
  7. H. Chen, T. Luo, X. Zhao, X. Lu, Y. Huo, and G. S. Kassab, Microstructural constitutive model of active coronary media, Biomaterials (Impact factor 7.604), 34:7575-83, 2013
  8. Y. Huo, X. Zhao, Y. Cheng, X. Lu, and G. S. Kassab, Two-layer model of coronary artery vasoactivity, Journal of Applied Physiology (Impact factor 4.235), 114:1451-1459, 2013
  9. Y. Huo, M. Svendsen, J. S. Choy, Z. D. Zhang, and G. S. Kassab, A validated predictive model of coronary fractional flow reserve, Journal of the Royal Society Interface (Impact factor 4.907), 9: 1325-1338, 2012
  10. Y. Huo and G. S. Kassab, Intraspecific scaling laws of vascular trees, Journal of the Royal Society Interface (Impact factor 4.907), 9: 190-200, 2012
  11. Y. Huo and G. S. Kassab, Compensatory remodeling of coronary microvasculature maintains shear stress in porcine left-ventricular hypertrophy, Journal of Hypertension (Impact factor 4.021), 30: 608-616, 2012
  12. Y. Huo, Y. Cheng, X. Zhao, X. Lu, and G. S. Kassab, Biaxial activity of porcine coronary artery, American Journal of Physiology - Heart and Circulatory Physiology (Impact factor 3.881), 302: H2058-2063, 2012
  13. Y. Huo, G. Finet, T. Lefevre, Y. Louvard, I. Moussa, and G. S. Kassab, Optimal diameter of diseased bifurcation segment: a practical rule for percutaneous coronary intervention, EuroIntervention (Impact factor 3.285), 7: 1310-1316, 2012
  14. Y. Huo, G. Finet, T. Lefevre, Y. Louvard, I. Moussa, and G. S. Kassab, Which diameter and angle rule provides optimal flow patterns in a coronary bifurcation? Journal of Biomechanics (Impact factor 2.463), 45: 1273-1279, 2012
  15. H. W. Choi, N. D. Farren, Z. D. Zhang, Y. Huo, and G. S. Kassab, Conductance catheter measurements of lumen area of stenotic coronary arteries: theory and experiment, Journal of Applied Physiology (Impact factor 4.235), 111: 758-65, 2011
  16. Z. D. Zhang, M. Svendsen, J. S. Choy, A. K. Sinha, Y. Huo, K. Yoshida, S. Molloi and  G. S. Kassab, New Method to Measure Coronary Velocity and Coronary Flow Reserve, American Journal of Physiology - Heart and Circulatory Physiology (Impact factor 3.881), 301: H21-H28, 2011
  17. G. Finet, Y. Huo, G. Rioufol, J. Ohayon, P. Guerin, and G. S. Kassab, Structure-function relation in the coronary artery tree: From fluid dynamics to arterial bifurcations, EuroIntervention (Impact factor 3.285), 6: J10-J15, 2010
  18. H. Zheng*, Y. Huo*, M. Svendsen, and G. S. Kassab, Effect of blood pressure on vascular hemodynamics in acute tachycardia, Journal of Applied Physiology (Impact factor 4.235), 109: 1619-1627, 2010 (*H. Zheng and Y. Huo contributed equally to this study)
  19. Y. Huo and G. S. Kassab, Effect of compliance and hematocrit on wall shear stress in a model of the entire coronary arterial tree, Journal of Applied Physiology (Impact factor 4.235), 107: 500-505, 2009
  20. Y. Huo, B. Kaimovitz, Y. Lanir, T. Wischgoll, J. I. E. Hoffman, and G. S. Kassab, Biophysical model of the spatial heterogeneity of myocardial flow, Biophysical Journal (Impact factor 4.218), 96: 4035-4043, 2009
  21. Y. Huo, J. S. Choy, M. Svendsen, A. K. Sinha, and G. S. Kassab, Effects of vessel compliance on flow pattern in porcine epicardial right coronary arterial tree, Journal of Biomechanics (Impact factor 2.463), 42: 594-602, 2009
  22. Y. Huo and G. S. Kassab, A scaling law of vascular volume, Biophysical Journal (Impact factor 4.218), 96: 347-353, 2009
  23. Y. Huo and G. S. Kassab, The scaling of blood flow resistance: from a single vessel to the entire distal tree, Biophysical Journal (Impact factor 4.218), 96: 339-346, 2009
  24. G. S. Kassab, J. S. Choy, M. Svendsen, A. K. Sinha, M. Alloosh, M. Sturek, Y. Huo, G. E. Sandusky, J. Hermiller, A novel system for the reconstruction of a coronary artery lumen profile in real time: a preclinical validation, American Journal of Physiology - Heart and Circulatory Physiology (Impact factor 3.881), 297: H485-492, 2009
  25. Y. Huo, X. Guo, and G. S. Kassab, The flow field along the entire length of mouse aorta and primary branches, Annals of Biomedical Engineering (Impact factor 2.376), 36: 685-699, 2008
  26. B. Kaimovitz*, Y. Huo*, Y. Lanir, and G. S. Kassab, Diameter asymmetry of porcine coronary arterial trees: structural and functional implications, American Journal of Physiology - Heart and Circulatory Physiology (Impact factor 3.881), 294: H714-H723, 2008 (*B. Kaimovitz and Y. Huo contributed equally to this study)
  27. Z. Liu, Y. Huo, J. A. Navia, and G. S. Kassab, A magnetic device to eliminate endograft migration: theory and experiment, Annals of Biomedical Engineering (Impact factor 2.376), 36:57-65, 2008
  28. Y. Huo, C. Linares, and G. S. Kassab, Capillary perfusion and wall shear stress are restored in the coronary circulation of hypertrophic right ventricle, Circulation Research (Impact factor 9.504), 100: 273-283, 2007
  29. Y. Huo, T. Wischgoll, and G. S. Kassab, Flow patterns in three-dimensional porcine epicardial coronary arterial tree, American Journal of Physiology - Heart and Circulatory Physiology (Impact factor 3.881), 293: H2959-H2970, 2007
  30. Y. Huo and G. S. Kassab, A hybrid one-dimensional/Womersley model of pulsatile blood flow in the entire coronary arterial tree, American Journal of Physiology - Heart and Circulatory Physiology (Impact factor 3.881), 292: H2623-H2633, 2007
  31. G.S. Kassab, Y. Huo, and G. Buckberg, Perfusion dynamics and clinically-relevant models of coronary flow distribution, Reply to the Editor, Journal of Thoracic and Cardiovascular Surgery (Impact factor 3.608), 133: 1396-1396, 2007
  32. Y. Huo and G. S. Kassab, Pulsatile blood flow in the entire coronary arterial tree: theory and experiment, American Journal of Physiology - Heart and Circulatory Physiology (Impact factor 3.881), 291: H1074-H1087, 2006

Journal Papers in Thermal/Fluids, CFD, and Multiphysics

  1. Y. Huo and B.Q. Li, Surface deformation and convection in electrostatically-positioned droplets of immiscible liquids under microgravity, ASME J. Heat Trans. (Impact factor 1.830), 128: 520-529, 2006
  2. Y. Huo and B.Q. Li, Boundary/finite element modeling of three-dimensional electromagnetic heating during microwave food processing, ASME J. Heat trans. (Impact factor 1.830), 127: 1159-1166, 2005
  3. Y. Huo and B. Q. Li, A mathematical model for Marangoni flow and mass transfer in electrostatically positioned droplets, Metallurgical and Materials Transactions B (Impact factor 0.903), 36B: 271-281, 2005
  4. Y. Huo and B. Q. Li, Three-dimensional Marangoni convection in electrostatically positioned droplets under microgravity, Int. J. Heat Mass Trans. (Impact factor 2.407). 47: 3533-3547, 2004
  5. Y. Huo, S. P. Song and B. Q. Li, Droplet deformation and 2-D/3-D Marangoni flow phenomena in droplets levitated by electric fields, Materials and Manufacturing Processes (Impact factor 1.058). 19: 761-775, 2004
  6. R. Akarapu, B. Q. Li, Y. Huo, J. Tang, and Frank Liu, Integrated modeling of microwave food processing and comparison with experimental measurements, J Microw Power Electromagn Energy, 39: 153-165, 2004
  7. B. Q. Li, Y. Huo, and X. Ai, Global and local stability of magnetically-levitated droplets, Jim Evans Honorary Symposium. Proceedings of the Symposium Sponsored by TMS, Pages: 343-350, 2010
  8. T. S. Lee, Z. Xu, and Y. Huo, Computer visualization of fluid circulation in annuli of heated rotating cylinders of low Prandtl number fluids, International Journal of Computational Engineering Science, 5: 357-378, 2004

Book Chapters

  1. Y. Huo and G. S. Kassab, Governing equations of blood flow and respective numerical methods, In Computational Cardiovascular Mechanics: Modeling and Applications in Heart Failure, edited by Julius M. Guccione, G S. Kassab, and M, Ratcliffe, Springer, 2010
  2. H. Y. Chen, L. Zhu, Y. Huo, Y. Liu, and G. S. Kassab, Fluid-structure interaction modeling in the cardiovascular system, In Computational Cardiovascular Mechanics: Modeling and Applications in Heart Failure, edited by Julius M. Guccione, G. S. Kassab, and M, Ratcliffe, Springer, 2010
  3. Z. Xu, Y. Huo, and T. S. Lee, Computer visualization of fluid circulation in annuli of heated rotating cylinders of low Prandtl number fluids, pp 108, In Recent Advances in Computational Science and Engineering, edited by H. P. Lee and K Kumar, 2002
  4. B. Kaimovitz, Y. Huo, Y. Lanir, and G. S. Kassab.  Structure-Function Relation of Coronary Vasculature, GS Kassab, and M. Sacks, eds., Structure-Based Models and Mechanics of Soft Tissue and Organs: A Tribute to Yoram Lanir. Springer, 2012

Professional Service

2005-present              Reviewer for ASME Journal of Heat Transfer

2007-present              Reviewer for ASME Journal of Biomedical Engineering

2007-present              Reviewer for AJP-Heart and Circulatory Physiology

2007-present              Reviewer for Engineering with Computers

2008-present              Reviewer for Journal of Applied Physiology

2008-present               Reviewer for Journal of General Physiology

2008-present               Reviewer for Annuals of Biomedical Engineering

2009-present               Reviewer for Journal of the Royal Society Interface

2009-present               Reviewer for ASME Journal of Thermal Science and Engineering Applications

2011-present               Reviewer for Cardiovascular Engineering and Technology

2011-present               Reviewer for Journal of Biomechanics

2011-present               Reviewer for ASME Journal of Dynamic Systems, Measurement and Control

2012-present               Reviewer for Biorheology

2009-present               Reviewer for many conference papers


Professional Affiliation

Member of ASME (American Society of Mechanical Engineering), BMES (Biomedical Engineering Society), AHA (American Heart Association), and SIGMA XI