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Peng Xi
Ph.D., Associate Professor
Department of Biomedical Engineering

Education

1994-1998  Shanxi University, Department of Electronic Engineering, Shanxi, China

1998-2003  Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai, China

Degree
 

BE  1998  Opto-electronic Engineering, Shanxi University

Ph. D.  2003  Optical Engineering, Chinese Academy of Sciences


Experience

2003. 8 – 2004.12  Research Associate, Department of Electrical and Electronic Engineering, Hong Kong University of Science and Technology, Kowloon, Hong Kong

2005. 2 – 2006.11  Research Associate, Bindley Bioscience Center, Purdue University, West Lafayette, IN.  
    

2006. 12 – 2007.12  Research Associate, Department of Chemistry, Michigan State University, East Lansing, MI.  

2008. 1 –  2009.11  Associate Professor,  School of Life Sciences and Biotechnology Shanghai Jiao-Tong University, Shanghai, China

 

2009. 12 –  now  Associate Professor,  Department of Biomedical Engineering, College of Engineering Peking University, Beijing, China 


Professional Memberships
 
2001  Optical Society of America

2008 Chinese Optical Society


Current Funded Research Projects

2012. 1 – 2015.12    Principal Investigator, National Science Foundation of China (No. 61176078)

Title: Quantum Dots with Giant Stokes Shifts for Super-Resolution Optical Imaging

2011. 6 – 2012. 6 Coulter Foundation GT-Emory-PKU BME Seed Grant
Title: Sub-diffraction limited imaging of single RNA sensitive probes using STED microscopy

2010. 1 – 2014.12 National “973”Project (No. 2010CB933901)
Title: Application of nanotechnology on the gastric cancer early diagnosis and prevention


Past Funded Research Projects

2009. 1 – 2011.12 Principal Investigator, National Science Foundation of China (No. 60808029)
Title: Confocal Reflectance / Fluorescence Real-time three-dimensional imaging system for dermatological diagnosis

2010. 6 – 2011. 6 Coulter Foundation GT-Emory-PKU BME Seed Grant
Title: Super-resolution Imaging of Cellular Dynamics with Quantum Dots and STED


2010. 9– 2011. 9 Peking University Medical-Engineering Joint Research Program
Title: The visualization study on the function of NAD(P)H on peroxide generation system

 


SCI-Indexed Journal Publications

  1. Y. Lu, P. Xi, J. A. Piper, Y., and D. Jin, “Time-Gated Orthogonal Scanning Automated Microscopy (OSAM) for High-speed Cell Detection and Analysis”, Scientific Reports (accepted).

  2. Y. Liu, Y. Ding, E. Alonas, W. Zhao, P. J. Santangelo, D. Jin, J. A. Piper,J. Teng, Q. Ren, P. Xi*, "Achieving λ/10 Resolution CW STED Nanoscopy with a Ti:Sapphire Oscillator" , PLoS ONE 7(6) e40003, 2012 (DOI: 10.1371/ journal. pone. 0040003). [Impact Factor 4.41]

  3. Y. Ding, H. Xie, T. Peng, Y. Lu, D. Jin, J. Teng, Q. Ren, P. Xi*, "Laser Obique Scanning Optical Microscopy (LOSOM) for Phase Relief Imaging" Optics Express, 20(13), 14100-14108, 2012. [Impact Factor 3.75]

  4. T. Peng, H. Xie, Y. Ding, W. Wang, Z. Li, D. Jin, Y. Tang, Q. Ren, P. Xi*, “CRAFT: multimodality confocal skin imaging for early cancer diagnosis.”, Journal of Biophotonics 5(5-6), 469-476 (2012) (SCI IF=4.24).

  5. H. Wang, X. Xu, X. Li, P. Xi*, Q. Ren, “Systematic design of a cross-polarized dermoscope for visual inspection and digital imaging”, IEEE Instrumentation and Measurement Magazine, 14(6)26-31 (2011).

  6. Y. Ding, P. Xi*, Q. Ren, “Hacking the optical diffraction limit: Review on recent developments of fluorescence nanoscopy”, Chinese Science Bulletin, 56(18) 1857-1876 (2011).

  7. P. Xi, K. Mei, T. Braeuler, C. Zhou, Q. Ren, “Evaluation of Spectrometric Parameters in Spectral-Domain Optical Coherence Tomography”, Applied Optics 50(3), 366-372 (2011).

  8. W. Wang, Y. Liu, P. Xi, Q. Ren, “The origin and effect of high-order dispersion in ultrashort pulse multiphoton microscopy in 10 femtosecond regime”, Applied Optics 49(35), 6703-6709 (2010).Cover paper.

  1. S. Chen, X. Feng, Y. Li, C. Zhou, P. Xi*, Q. Ren, “Software controlling algorithms for the system performance optimization of confocal laser scanning microscope”, Biomedical Signal Processing and Control, 5(3) 223-228 (2010).

  2. Z. Li, P. Huang, X. Zhang, J. Lin, S. Yang, B. Liu, F. Gao, P. Xi, Q. Ren and D. Cui, “RGD-Conjugated Dendrimer-Modified Gold Nanorods for in Vivo Tumor Targeting and Photothermal Therapy”,. Molecular Pharmaceutics, 7(1) 94-104 (2010). [SCI IF=5.408, Cited: 23].

  3. Z. Li, P. Huang, X. Zhang, J. Lin, R. He, B. Liu, X. Zhang, S. Yang, P. Xi, X. Zhang, Q. Ren and D. Cui,  “Arginine-Glycine-Aspartic Acid-Conjugated Dendrimer-Modified QuantumDots for Targeting and Imaging Melanoma”,  Journal of Nanoscience and Nanotechnology, 10(8), 4859-4867 (2010)

  4. Y. Shang, Z. Wang, Y. Pang, P. Xi*, Q. Ren*, “The role of mast cells in non-ablative laser resurfacing with 1,320 nm neodymium:yttrium– aluminium –garnet laser”, Lasers in Medical Science (2009).

  5. M. Jiang, C. Zhou, W. Wang, P. Xi, Q. Ren, “Comparative analysis of Zernike aberrations generation with deformable mirrors for ocular adaptive optics”, J. Modern Optics, 56(16) 1741-1746 (2009).

  6. P. Xi, Y. Andegeko, D. Pestov, V. V. Lozovoy, M. Dantus, " Two-photon imaging using adaptive phase compensated ultrashort laser pulses", Journal of Biomedical Optics 14(1) 014002, (2009) [SCI IF=3.188, Cited: 9].

  7. P. Xi, Y. Andegeko, L. R. Weisel, V. V. Lozovoy, M. Dantus, "Greater signal, increased depth, and less photobleaching in two-photon microscopy with 10 femtosecond pulses", Optics Communications 281(4), 1841-1849 (2008). [SCI IF=1.517, Cited: 26]

  8. P. Xi, B. Rajwa, J. Jones, J. P. Robinson, “The design and construction of a cost-efficient confocal microscope”, American J. Physics, 75(3), 203-207 (2007). [SCI IF=0.889, Cited: 1]

  9. Y. Wu, P. Xi, J. Qu, et al., “Depth-resolved fluorescence spectroscopy of normal and dysplastic cervical tissue,” Optics Express, 13 (2), 382-388 (2005)  [SCI IF=3.709, Cited: 22]

  10. Y. Wu, P. Xi, J. Y. Qu, T. Cheung, and M. Yu, “Depth-resolved fluorescence spectroscopy reveals layered structure of tissue,” Opt. Express 12(14), 3218-3223, 2004. [SCI IF=3.749, Cited: 35]

  11. E. Dai, P. Xi, C. Zhou, L. Liu, “Multifunctional double-layered diffractive optical element”, Opt. Lett., 28(17), 1513-1515, 2003.  [SCI IF=3.711, Cited: 16]

  12. P. Xi, C. Zhou, E. Dai, L. Liu, “Generation of near field hexagonal array illumination”, Opt. Lett., 27(4), 228-230, 2002. [SCI IF=3.711, Cited: 29]

  13. P. Xi, C. Zhou, E. Dai, L. Liu, “A novel method for ultrashort laser pulse-width measurement based on self-diffractive effect”, Opt. Express, 10(20), 1099-1104, 2002. [SCI IF=3.709, Cited: 12]

  14. P. Xi, C. Zhou, S. Zhao, L. Liu, “Phase contrast hexagonal array illumination”, Opt. Comm., 192(3~6) 193-197, 2001. [SCI IF=1.314, Cited: 3]

  15. C. Zhou, P. Xi, S. Zhao, L. Liu, “Simple equations for pi-phase-modulated Talbot illuminator”, Microwave & Optical Technology Letters, 29(1), 49-52, (2001). [SCI IF=0.631]

  16. S. Zhao, C. Zhou, P. Xi, H. Wang, L. Liu "Number of phase levels in a two-dimensional separable Talbot array illuminator", J. Opt. Soc. Am. A, 2001, 18(1): 103~107 [SCI IF=1.776, Cited: 2]

  17. C. Zhou, H. Wang, S. Zhao, P. Xi, L. Liu, “Number of Phase Levels of a Talbot Array Illuminator”, Appl. Opt., 40(5), 607-613, 2001. [SCI IF=1.701,Cited: 14]

  18. H. Wang, C. Zhou, S. Zhao, P. Xi, and L. Liu, “The temporal Fresnel diffractive field of a grating illuminated by an ultrashort pulsed-laser beam”, J. Opt. A: Pure Appl. Opt. 3, 159-163 (2001). [SCI IF=1.752, Cited: 9]

Book Chapter:

Peng Xi, Yujia Liu, Qiushi Ren, “Scanning and image reconstruction techniques in confocal laser scanning microscopy”, in Laser Scanning, Theory and Applications, ISBN 978-953-7619-X-X.

EI-indexed Journal Publications and Conference Proceedings:

  1. P. Xi, “How to Obtain Super-Resolution Nanoscopy”, Molecular Medical Imaging Workshop 2012. [Invited Speech]

  2. P. Xi, “λ/10 Wavelength Super-Resolution Nanoscopy”, PKU-YNU Joint Symposium 2012. [Invited Speech]

  3. P. Xi, “λ/10 Resolution CW STED Nanoscopy and Its Application in Cellular Imaging”, iCeMS Joint Symposium 2012. [Invited Keynote Speech]

  4. Y. Liu, P. Xi, “OPTICAL NANOSCOPY BY CONTINUOUS WAVE STIMULATED EMISSION DEPLETION (CW STED) WITH A TI:SAPPHIRE OSCILLATOR”, iCeMS Joint Symposium 2012.

  5. T. Peng, H. Xie, Y. Ding, W. Wang, Z. Li, D. Jin, Y. Tang, Q. Ren, P. Xi*, “Confocal Reflectance/ Auto-Fluorescence Tomograpy (CRAFT) for Early Skin Cancer Diagnosis”, BIOMED 2012.

  6. Y. Liu, Y. Ding, E. Alonas, W. Zhao, P. J. Santangelo, D. Jin, J. A. Piper,J. Teng, Q. Ren, P. Xi* “OPTICAL NANOSCOPY BY CONTINUOUS WAVE WAVE STIMULATED EMISSION DEPLETION (CW STED) WITH A TI:SAPPHIRE LASER”, Focus On Microscopy 2012.

  7. T. Peng, H. Xie, Y. Ding, Q. Ren, P. Xi*, “Confocal Reflectance/ Auto-Fluorescence Tomography and its Application on Early Skin Cancer Diagnosis”, Focus On Microscopy 2012.

  8. P. Xi, Y. Liu, W. Wang, H. Wang, Q. Ren, “Adaptive phase compensation in multiphoton microscopy” Focus On Microscopy 2010, Shanghai, China.

  9. P. Xi, Y. Andegeko, D. Pestov, V. V. Lozovoy, M. Dantus, X. Feng, C. Zhou, Q. Ren, “Multiphoton microscopy with phase compensated ultrashort laser pulses”, Focus On Microscopy 2009, Krakow, Poland.

  10. X. Feng, B. Gao, P. Xi, C. Zhou, Y. Li, S. Chen, Q. Ren, “Multimodality confocal imaging and its application in revealing biomedical histopathology”, Focus On Microscopy 2009, Krakow, Poland.

  11. P. Xi, C. Zhou, X. Feng, W. Wang, M. Jiang, Tobias Braeuler?Q. Ren, “Multiphoton microscopy with 10 fs pulse in biomedical imaging”, Acta Optica Sinica, (In Chinese).

  12. Y. Liu, Y. Ding, H. Wang, W. Wang, H. Xie, Q. Ren, P. Xi* “Optical nanoscopy by continuous wave stimulated emission depletion  (CW STED) with a Ti:Sapphire Laser”, POEM 2011 Wuhan, China. (Yujia Liu won the Best Student Paper Award)

  13. Y. Liu, Y. Ding, H. Wang, W. Wang, H. Xie, Q. Ren, P. Xi*, “Breaking the optical resolution barrier by stimulated emission depletion in China”, Cold Spring Harbor Conference Asia 2011.

  14. W. Wang, Tobias Braeuler, P. Xi, C. Zhou, M. Jiang, Q. Ren, “Frequency-domain optical coherent tomograph and the application in ophthalmology”, Chinese Journal of Lasers, (In Chinese).

  15. P. Xi, L. R. Weisel, Y. Andegeko, D. Schlam, V. V. Lozovoy, M. Dantus, "Two-Photon Laser Scanning Microscopy with Ultrabroad Bandwidth 110 nm FWHM Femtosecond Pulses", Photonics West, San Jose, USA (2008).

  16. P. Xi, Y. Andegeko, L. R. Weisel, B. Xu, J. Pote, R. M. Martin, M. Dantus, "Multi-photon microscopy in biological tissue with ultrashort shaped pulses", Frontiers in Optics (FiO), San Jose, USA (2007). 

  17. L. R. Weisel, P. Xi, Y. Andegeko, D. Schlam, R. M. Martin, V. V. Lozovoy, M. Dantus, "Biomedical imaging with selective two-photon excitation", 234th ACS National Meeting, Boston, USA (2007).

  18. L. R. Weisel, R. M. Martin, L. T. Shelhas, P. Xi, M. Dantus, "Selective Two-Photon Excitation for Biomedical Imaging", Conference on Lasers and Electro-Optics (CLEO), Baltimore, USA (2007).  

  19. P. Xi, S. Leavesley, B. Rajwa, T. Bernas, W. T. Bee, J. Jones, J. P. Robinson, “Construction of a simple confocal microscope with embedded quantitative fluorescence measurement,” ISAC XXIII International Congress (2006).

  20. P. Xi, S. Leavesley, M. Fu, J. P. Robinson, “Quantitative concentration ratio measurement of ocular autofluorescence”, Great Lake International Imaging and Flow Cytometry Association (2005)

  21. P. Xi, Y. Wu, J. Y. Qu, P. Yuen, “Confocal autofluorescence spectroscopy of biological tissues”, Conference on Lasers and Electro-Optics (CLEO) 2004, San Francisco, USA.

  22. P. Xi, C. Zhou, H. Luo, E. Dai, L. Liu, “Near field detection of the quality of high-density gratings with nanotechnology”, SPIE 2003, Vol. 5225, 140-144.

  23. J. Zu, C. Zhou, P. Xi, E. Dai, L. Liu, “Wavelength-division and beam splitting element based on the Talbot effect”, Acta Optica Sinica, 23(4), 431-433 (2003). (In Chinese)

  24. Y. Wu, P. Xi, J. Y. Qu, W. Ge, P.Yuen, “Fluorescence spectroscopy of biological tissue: single- and two-photon excitation”, Photonic West 2003, San Jose, USA.

  25. C. Zhou, Y. Zhang, P. Xi, E. Dai, X. Wu, L. Liu, “Symmetric color separation gratings”, SPIE 2003, Vol. 5201, 174-179.

  26. X. Sun, C. Zhou, P. Xi, E. Dai, L. Liu, B. Yu, “Fabrication of optical elements with femtosecond doubled-frequency Ti: Sapphire laser”, SPIE 2003, Vol.5174, 187-193.

  27. X. Wu, C. Zhou, P. Xi, E. Dai, H. Ru, L. Liu, “Etching quartz with inductively coupled plasma etching equipment”, SPIE 2003, Vol. 5183, 192-198.

  28. P. Xi, C. Zhou, E. Dai, L. Liu, “New pulse-width measurement for ultrashort laser pulse”, OSA Diffractive-optics & Micro-optics Meeting, 2002.

  29. P. Xi, C. Zhou, E. Dai, L. Liu, “Ultrafast study of near field hexagonal array illumination”, SPIE 2002, Vol. 4929, 116-123.

  30. C. Zhou, P. Xi, E. Dai, L. Liu, “Laser beam scanning based on the Talbot phase encoding method”, SPIE 2002, Vol. 4788, 50-57.

  31. E. Dai, C. Zhou, P. Xi, L. Liu, “Fast and effective algorithm for synthesizing computer generated holograms”, SPIE 2002, Vol. 4768, 164-169.

  32. E. Dai, C. Zhou, P. Xi, L. Liu, “Space multiplexed diffractive optical device based on Talbot effect”, SPIE 2002, Vol. 4929, 26-30.

  33. J. Jia, C. Zhou, W. Xu, P. Xi, “Superresolution technology for small diffraction spot size in the far field”, SPIE 2002, Vol. 4825, 131-138.

  34. P. Xi, C. Zhou, S. Zhao, H. Wang, L. Liu, “Design and Fabrication of 64×64 Spot Array Dammann Grating”, Chin. J. Las., A28(4) 369-371, 2001. (In Chinese)

  35. P. Xi, C. Zhou, S. Zhao, E. Dai, L. Liu, “Pulse-width measurement of ultrashort laser based on Talbot effect”, SPIE 2001, Vol. 4438, 116-123.

  36. C. Zhou, P. Xi, E. Dai, L. Liu, H. Ru, “Phase gratings made with inductively coupled plasma technology”, SPIE 2001, Vol. 4470, 138-145.

  37. S. Zhao, C. Zhou, P. Xi, L. Liu, “Decomposing rule of two-dimensional separable Talbot array illuminator”, SPIE 2001, Vol. 4438, 191-197.

  38. S. Zhao, C. Zhou, P. Xi, L. Liu “Possibility of phase-contrast pickup head for two-layered optical disk”, SPIE 2001, Vol. 4470, 225-230.

  39. E. Dai, C. Zhou, P. Xi, S. Zhao, L. Liu, “Initial phase assignment method for synthesizing computer generated hologram”, SPIE 2001, Vol. 4436, 231-236.

  40. C. Zhou, H. Wang, P. Xi, S. Zhao, L. Liu, “Arbitrary-phase-modulated Talbot illuminator”, SPIE 2000, Vol. 4114, 140-145.

  41. H. Wang; C. Zhou; S. Zhao, P. Xi, L. Liu, “Time dependence of Talbot effect under ultrashort laser illumination”, SPIE 2000, Vol. 4114, 230-235.

Patents:

  1. S. Leavesley, J. P. Robinson, P. Xi, “Endoscopic imaging device”, US Patent Application No. US20090012369A1.

  2. C. Zhou, P. Xi, L. Liu, Ultrashort laser pulse time interval measuring method, Patent No. CN1317686A (Invent patent). (In Chinese)

  3. C. Zhou, P. Xi, L. Liu, hexagonal phase array illumination method, Patent No. CN1348113A (Invent Patent). (In Chinese)

  4. C. Zhou, L. Liu, P. Xi, Phase plates for beam scanner, Patent No. CN1317702A (Invent patent). (In Chinese)

  5. C. Zhou, L. Liu, P. Xi, Phase plates fabricated with binary optics technology,  Patent No. CN2492860Y (Application Patent). (In Chinese)


Biography

Dr. Peng Xi was graduated from Shanxi University, Taiyuan, China with Bachelor degree in Optical Engineering in July 1998.  From September 1998 to July 2003, he studied at Laboratory of Information Optics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai, China for his Ph. D. degree. He then worked as a postdoctoral Research Associate in Hong Kong University of Science and Technology, Hong Kong, China from August 2003 to December 2004, where he studied the early detection of human cervical cancer with confocal depth-resolved spectroscopy. From February 2005 to November 2006 he worked in Bindley Bioscience Center, Purdue University as a postdoctoral Research Associate, where he developed a compact confocal laser scanning system and designed an endoscope for both macroscopic and microscopic view simultaneously. From December 2006 to December 2007 he worked in Michigan State University as a postdoctoral Research Associate, and for the first time he reported the application of a 10 fs ultrashort laser in multiphoton microscopy with high-order dispersion compensation. From Jan. 2008 to Nov. 2009 he worked in the Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China as an Associate Professor. He is now working in Dept. of Biomedical Engineering, College of Engineering, Peking University as an Associate Professor.

Dr. Peng Xi’s research are sponsored by National Science Foundation of China, and Shanghai Pujiang Talent Program. He also co-chaired one “863” Program, Coulter Foundation GT-Emory-PKU BME Seed Grant, and Peking University Medical-Engineering Joint Research Program, and participated in two “973” Programs.

Dr. Peng Xi’s current research interests are focused on research and development of optical nanoscopy, multiphoton microscopy, as well as novel biomedical optical imaging techniques for the early diagnosis of major diseases such as cancer. Dr. Peng Xi has published over 50 scientific papersin peer-reviewed journals and conference proceedings, and received 4 patents. His H-index is currently 10.

Dr. Peng Xi is on the editorial board of two international journals: Datasets Papers in Optics and Journal of Physical Chemistry and Biophysics. He has been serving as a reviewer for a series of peer-reviewed scientific journals such as: Optics Letters, Optics Express, Journal of Optical Society of America B, Optics Communications, and Applied Optics. He has been invited to give several keynote speeches and be the chairs of many international conference sessions.