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Zuhong Lu
Ph.D., Professor
Department of Biomedical Engineering
  • Office Add: Room 511 No.1 Building of College of Engineering
  • Office Tel: +86-10-62756160
  • Email: zuhonglu@coe.pku.edu.cn
Education
 
Feb. 1985 – Dec. 1988 Ph.D. Biomedical Engineering, Southeast University
Jan.1982 - July 1984 Electronics, Southeast University
Jan.1978 – Jan.1982 B.S Electronics, Southeast University, China

Professional Experience

Sep. 2012- Present  Chair Professor, College of Engineering, Peking University, China
July 2002  - June 2008  Professor and Director, State Key Laboratory for Bioelectronics, Southeast University
Feb.1992- July 2002  Professor and Director, Key Laboratory for Molecular and Biomolecular Electronics of Ministry of Education, Department of Biological Science and Medical Engineering, Southeast University
Oct. 1988 – Feb. 1992  Faculty member, Department of Biological Science and Medical Engineering, Southeast University

Research Areas and Interests

Biosensors and bio-instruments
Microarray technologies and New generation DNA sequencing
Cross-omics analysis, biomedical modeling

Research Profile

The overall objective of the research in the Lu group is focused on developing various novel high-throughput technologies for fundamental biological studies and biomedical or clinical applications. We have developed several microarray technologies for detection of genomic DNA methylation, functional single nucleotide polymorphysms (SNPs), multiple viruses, DNA binding proteins, capturing and identifying cells in various clinical samples. More recently, we developed the novel instruments and assays of new generation DNA sequencing. We are also developing the microdroplet systems for single cell sequencing and haplotype sequencing.  

The algorithm and software tools are developed for analyzing and integrating the different omics data from biological and clinical samples, such as RNA-seq, ChIP-seq, etc. We try modeling the gene regulation networks and understanding the genomic evolution from the new angles. Furthermore, we will integrate high throughput molecular information and meta-medical information together in order to lead the future health informatics for personal medicine.


Professional Activities

• Member of Editor board: IEEE Transaction on Nanobioscience, and IET nanobiotechnology
• Secretary General of Chinese Society of Biomedical Electronics, IOE of China

Selected Publications

(1) H. Wang, J. Li, H. Liu, Q. Liu, Q. Mei, Y. Wang, J. Zhu, N. He and Z. Lu?Label-free hybridization detection of a single nucleotide mismatch by immobilization of molecular beacons on an agarose film?Nucleic Acid Research. 2002, 30:e61?
(2) P. Xiao, N. He, Z. Lu, In situ synthesis of oligonucleotide arrays by using soft lithography. Nanotechnology. 2002, 13: 756-762
(3) J. Ma, T. Zhou, W. Gu, X. Sun?and Z. Lu?“Cluster analysis of the codon use frequency of MHC genes from different species”?Biosystems?2002, 65:199-207
(4) P. Hou, M. Ji, C. Ge, J. Shen, S. Li, N. He and Z. Lu, Detection of methylation of human p16Ink4a gene 5’-CpG islands by electrochemical method coupled with linker-PCR, Nucleic Acids Research. 2003, 31:e92
(5) C. Zhang, Y. Zhang, X. Wang, Z. Tang and Z. Lu, Hyper-rayleigh scattering of protein-modified gold nanoparticles, Analytical Biochemistry. 2003, 320:136-140
(6) C. Zhang, H. Liu, Z. Tang, N. He, and Z. Lu, Cell detection based on protein array using modified glass slides, Electrophoresis. 2003,  24:3279-3283
(7) T. Li, J. Wang, Y. Bai, X. Sun, and Z. Lu, A novel method for screening species-specific gDNA probes for species identification, Nucleic Acids Research.  2004, 32:e42
(8) W. Gu, T. Zhou, J. Ma, Xiao Sun, and Z. Lu. Analysis of synonymous codon usage in SARS coronavirus and other viruses in the nidovirales, Virus Research. 2004, 101: 155–161
(9) Y. Zhu, H. Zeng, J. Xie, L. Ba, X. Gao, and Z. Lu, Atomic Force Microscopy studies on DNA structural changes induced by vincristine sulfate and aspirin, Microscopy and Microanalysis. 2004, 10: 286-290
(10) M. Ji , P. Hou , S. Li , N. He and Z. Lu?Microarray-based method for genotyping of functional single nucleotide polymorphisms using dual-color fluorescence hybridization?Mutation Research. 2004, 548:97-105
(11) Q. Liu, Q. Zhou, Y. Bai, Q. Ge, and Z. Lu,  Detection and analysis system for hybridization images of Lab-in-a-Tube microarray? Chinese Science Bulletin. 2005, 50: 2896-2900
(12) H. Liu, H. Wang, Z. Shi, H. Wang, C. Yang, S. Silke, W. Tan and Z. Lu, TaqMan probe array for quantitative detection of DNA targets, Nucleic Acids Research. 2006, 34: e4
(13) P. Hou, M. Ji, B. Yang, Z. Chen, J. Qiu, X. Shi, and Z. Lu, Quantitative Analysis of Promoter Hypermethylation in Multiple Genes in Osteosarcoma, Cancer. 2006, 106:1602-1609
(14) T. Zhou, X. Sun, Z. Lu, “Synonymous codon usage in environmental chlamydia UWE25 reflects an evolutional divergence from pathogenic chlamydiae ”GENE. 2006, 368:117-125
(15) P. Jiang, H. Wu, W. Wang, W. Ma, X. Sun, Z. Lu, MiPred: classification of real and pseudo microRNA precursors using random forest prediction model with combined features, Nucleic Acids Research. 2007, 35: W339-W344
(16) P. Jiang, H. Wu, J. Wei, F. Sang, X. Sun, and Z. Lu, RF-DYMHC: detecting the yeast meiotic recombination hotspots and coldspots by random forest model using gapped dinucleotide composition features, Nucleic Acids Research. 2007, 35: W47-W51
(17) Q. Liu, Y. Bai, Q. Ge, S. Zhou, T. Wen, and Z. Lu?Microarray-in-a-tube for Detection of Multiple Viruses, Clinical Chemistry. 2007, 53:188-194
(18) Y. Wan, Y. Wang, P. Xiao, Z. Lu, Bisulfite modification of immobilized DNAs for methylation detection, Biosensors and Bioelectronics. 2007, 22:2415-2421
(19) P. Hou, Z. Chen, M. Ji, N. He, Z. Lu, Real-time PCR Assay for Ultrasensitive Quantification of DNA-Binding Proteins, Clinical Chemistry, 2007 53, 581–586
(20) D. Zhang, Y. Wang, Y. Bai, Q. Ge, Y. Qiao, J. Luo, C. Jia, and Z. Lu?A novel method to quantify local CpG methylation density by regional methylation elongation assay on microarray?BMC Genomics. 2008, 9:59
(21) Y. Wang, D. Zhang, W. Zheng, J. Luo, Y. Bai, and Z. Lu, Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray?Cancer. 2008, 112:1325-1336
(22) J. Tang, Y. Li, Z. Pan, Y. Guo, J. Ma, S. Ning, P. Xiao, and Z. Lu, Single nucleotide variations detection by ligation of universal probes on 3-D polyacrylamide gel DNA microarray, Human mutation.  2009, 30:1460-1468
(23) J. Tu, Y. Bai, Q. Ge, Q. Yang, and Z. Lu?2-Color Encoding Solid Phase Minisequencing?Journal of Nanoscience and Nanotechnology. 2010, 10:1–3
(24) Y. Yang, W. Wang, Y. Li, J. Tu, Y. Bai, P. Xiao, D. Zhang, and Z. Lu, Identification of methylated regions with peak search based on Poisson model from massively parallel methylated DNA immunoprecipitation -sequencing data, Electrophoresis. 2010, 31: 3537–3544
(25) W. Wang, D. Zhou, X. Shi, C. Tang, X. Xie, J. Tu, Q. Ge, and Z. Lu, Global Egr1-miRNAs Binding Analysis in PMA-Induced K562 Cells Using ChIP-Seq, Journal of Biomedicine and Biotechnology. 2010, 2010: Article ID 867517
(26) C. Tang?X. Shi?W. Wang?D. Zhou?J. Tu?X. Xie?Q. Ge?P. Xiao?X. Sun?and Z. Lu?Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing?Electrophoresis. 2010, 31:2936–2943
(27) L. Guo, Z. Lu?Global expression analysis of miRNA gene cluster and family based on isomiRs from deep sequencing data?Computational Biology and Chemistry. 2010, 34: 165–171
(28) W. Wang, X. Shi, and Z. Lu?Simulation of ChIP-Seq based on extra-sonication of IPed DNA fragments, Chinese Science Bulletin. 2010, 55:2380-2389
(29) L. Guo, T. Liang, Z. Lu, A comprehensive study of multiple mapping and feature selection for correction strategy in the analysis of small RNAs from SOLiD sequencing. BioSystems, 2011, 104: 87-93